听力与言语-语言病理学

行为科学

医学伦理学

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  • Variable splicing of non-coding roX2 RNAs influences targeting of MSL dosage compensation complexes in Drosophila.

    abstract::The non-coding roX1 and roX2 RNAs are components of the MSL dosage compensation complex in Drosophila. We found that multiple species of roX2 RNA are produced by alternative splicing, with one major and at least 20 different minor forms associated with MSL proteins. The alternative forms are generated by variable usag...

    journal_title:RNA biology

    pub_type: 杂志文章

    doi:10.4161/rna.2.4.2473

    authors: Park Y,Oh H,Meller VH,Kuroda MI

    更新日期:2005-10-01 00:00:00

  • QUAKING KH domain proteins as regulators of glial cell fate and myelination.

    abstract::The quaking viable (qk(v)) mice have attracted attention because of their characteristic tremor caused by their dysmyelination. In the central nervous system, qk(v) mice fail to develop mature myelinating oligodendrocytes and display uncompacted myelin. The genetic defect in the qk(v) mice prevents the proper expressi...

    journal_title:RNA biology

    pub_type: 杂志文章,评审

    doi:10.4161/rna.2.2.1603

    authors: Larocque D,Richard S

    更新日期:2005-04-01 00:00:00

  • RNA repair--the latest addition to the toolbox for macromolecular maintenance.

    abstract::All organisms must keep their DNA intact and free of lesions to obtain faithful transmission of genetic information, and many cellular proteins are involved in genome maintenance. However, also other macromolecules may be subject to repair. Deleterious lesions in proteins can be reversed by several mechanisms, and thi...

    journal_title:RNA biology

    pub_type: 杂志文章

    doi:10.4161/rna.2.1.1602

    authors: Falnes PØ

    更新日期:2005-01-01 00:00:00

  • FMR1 RNA within the intranuclear inclusions of fragile X-associated tremor/ataxia syndrome (FXTAS).

    abstract::Fragile X-associated tremor/ataxia syndrome (FXTAS) is a recently identified neurodegenerative disorder affecting older adult males with premutation alleles of the fragile X mental retardation 1 (FMR1) gene. The principal clinical features of FXTAS include progressive intention tremor, gait ataxia, parkinsonism, and a...

    journal_title:RNA biology

    pub_type: 杂志文章

    doi:10.4161/rna.1.2.1035

    authors: Tassone F,Iwahashi C,Hagerman PJ

    更新日期:2004-07-01 00:00:00

  • Nonsense mediated decay induced by tethered human UPF3B is restricted to the cytoplasm.

    abstract::The subcellular localization of the nonsense mediated decay (NMD) of mRNA transcripts bearing premature termination codons has been controversial. Recently, it has been demonstrated that RNA tethering of key mediators of NMD, including human UPF3B, accurately recreates NMD. Here, we have used tethered UPF3B, combined ...

    journal_title:RNA biology

    pub_type: 杂志文章

    doi:

    authors: Lu S,Cullen BR

    更新日期:2004-05-01 00:00:00

  • Synthesis of cysteinyl-tRNACys by a prolyl-tRNA synthetase.

    abstract::The question of how cysteinyl-tRNA(Cys) is synthesized in organisms that lack a canonical cysteinyl-tRNA synthetase (CysRS) is an important open question in understanding protein synthesis. The prolyl-tRNA synthetase (ProRS) of wide ranging organisms has the ability to mis-activate cysteine without editing. This raise...

    journal_title:RNA biology

    pub_type: 杂志文章

    doi:

    authors: Zhang CM,Hou YM

    更新日期:2004-05-01 00:00:00

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